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Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
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A brief physical activity protects against ischemic stroke.

Henry Zhang1, Jea-Young Lee1, Cesar V Borlongan1

  • 1Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.

Brain Circulation
|October 18, 2019
PubMed
Summary

A short bout of exercise before ischemic stroke improved motor function and reduced brain damage in rats. This suggests physical activity may enhance cerebrovascular strength for neuroprotection against stroke.

Keywords:
Angiogenesiscerebral blood flowcerebrovasculatureexerciseischemic strokemiddle cerebral artery occlusionneuroprotectionphysical activity

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Area of Science:

  • Neuroscience
  • Cardiovascular Science
  • Exercise Physiology

Background:

  • Stroke is a critical disease with limited therapeutic options.
  • Ischemic strokes cause significant cerebrovascular damage.
  • Maintaining cerebral vasculature health, including angiogenesis, may offer protection.

Purpose of the Study:

  • To investigate the neuroprotective effects of exercise prior to ischemic stroke.
  • To determine if pre-stroke exercise impacts stroke outcomes and brain recovery.

Main Methods:

  • Sprague-Dawley rats were divided into exercise and control groups before inducing middle cerebral artery occlusion (MCAO).
  • Evaluated motor performance, cellular activity in the peri-infarct region, infarct size, angiogenesis, and neuroprotection.

Main Results:

  • Rats exercising before MCAO showed better motor performance and reduced infarct size.
  • Exercise group exhibited increased cellular activity and heightened angiogenesis in the peri-infarct area.
  • Enhanced neuroprotection and improved cerebrovascular strength were observed in the exercise group.

Conclusions:

  • A brief period of exercise before ischemic stroke can offer significant neuroprotection.
  • Exercise may mitigate stroke effects by strengthening the cerebrovasculature and promoting angiogenesis.
  • This finding suggests exercise as a potential preventative strategy against ischemic stroke.