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Updated: Jan 5, 2026

The Role of Indocyanine Green Fluorescence in Complex Laparoscopic Cholecystectomy Navigation
Published on: January 31, 2025
[Intraoperative fluorescence angiography in colorectal surgery].
1Klinik für Allgemein-, Visceral- und Gefäßchirurgie, Elisabeth-Krankenhaus, Klosterstr. 4, 49832, Thuine, Deutschland. thomas.carus@niels-stensen-kliniken.de.
Indocyanine green fluorescence angiography (ICG-FA) in colorectal surgery significantly reduces anastomotic leakage rates. This study
Area of Science:
- Surgical Innovation
- Medical Imaging
- Gastrointestinal Surgery
Background:
- Indocyanine green fluorescence angiography (ICG-FA) is a valuable tool for assessing anastomotic perfusion in colorectal surgery.
- Previous studies indicate a low anastomotic leakage rate with ICG-FA, such as the PILLAR II study (1.4%).
- This article presents original findings on ICG-FA efficacy and application in colorectal procedures.
Purpose of the Study:
- To evaluate if current ICG-FA results support its expanded use in colorectal surgery.
- To determine the impact of ICG-FA on anastomotic leakage rates.
Main Methods:
- A total of 378 colorectal resections (280 colon, 98 rectal) were performed between July 2009 and June 2019.
- Intraoperative assessment of anastomosis perfusion using ICG-FA was conducted.
- In 13 patients (3.4%), reduced perfusion detected by ICG-FA led to procedural changes.
Main Results:
- The overall anastomotic leakage rate was 3.7% (8 leaks in colon, 6 in rectum).
- Without intraoperative adjustments guided by ICG-FA, the leakage rate could have reached 7.1%.
- ICG-FA use potentially reduced the leakage rate by 48% in the studied cohort.
Conclusions:
- ICG-FA demonstrates a very low anastomotic leakage rate in colorectal surgery.
- While promising, further controlled randomized studies are needed before widespread recommendation.
- ICG-FA shows potential for improving outcomes in colorectal surgery.
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