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Updated: Jan 5, 2026

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
Published on: March 12, 2020
Resources for Chemical, Biological, and Structural Data on Natural Products
Ya Chen1, Christina de Bruyn Kops2, Johannes Kirchmair3,4
1Faculty of Mathematics, Informatics, and Natural Sciences, Department of Computer Science, Center for Bioinformatics, Universität Hamburg, Hamburg, Germany.
Abstract:
Natural products from plants, marine life, animals, fungi, bacteria, and other organisms remain the most productive source of inspiration for small-molecule drug discovery. Today, a wealth of information on natural products that is particularly valuable to applications in cheminformatics is at our disposal. In this contribution, we provide a timely overview of relevant resources for measured chemical, biological, and structural data on natural products. In particular, we comment on the accessibility, scope, chemical space, and limitations of the individual data sources. The bottleneck of natural products remains the limited availability of material for testing. In this context, we analyze the number of natural products readily obtainable from commercial and other sources.
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