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Wilhelm Uhthoff and Uhthoff's phenomenon.

Aarushi Jain1, Mattia Rosso2, Jonathan D Santoro3

  • 1Boston University, Boston, MA, USA.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|October 18, 2019
PubMed
Summary

Uhthoff's phenomenon causes temporary vision blurring in multiple sclerosis patients due to heat or exercise. This review explores the phenomenon

Keywords:
UhthoffUhthoff’s phenomenonbiographymultiple sclerosisoptic neuritis

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Area of Science:

  • Neurology
  • Neuro-ophthalmology

Background:

  • Wilhelm Uhthoff was a German ophthalmologist specializing in neurologic disorders.
  • Uhthoff's phenomenon describes transient vision blurring in multiple sclerosis (MS) patients.
  • The phenomenon is triggered by heat, exercise, and other homeostatic disruptions.

Purpose of the Study:

  • To review the life and career of Wilhelm Uhthoff.
  • To discuss the underlying basis of Uhthoff's phenomenon.

Main Methods:

  • Literature review of Uhthoff's contributions.
  • Discussion of the physiological basis of Uhthoff's phenomenon.

Main Results:

  • Uhthoff's phenomenon is a well-documented symptom in multiple sclerosis.
  • The phenomenon is linked to disruptions in body temperature regulation.

Conclusions:

  • Understanding Uhthoff's phenomenon provides insight into MS pathophysiology.
  • Further research into heat sensitivity in MS is warranted.