Transition metal-catalyzed sp3 C-H activation and intramolecular C-N coupling to construct nitrogen heterocyclic
Ming Zhang1, Qiuhong Wang1, Yiyuan Peng1
1College of Chemistry and Chemical Engineering and Key Laboratory of Functional Small Organic Molecules, Ministry of Education, Jiangxi Normal University (Yaohu campus), 99 Ziyangdadao Avenue, Nanchang, Jiangxi 330022, China. zmchem@163.com.
Abstract:
Nitrogen heterocycles are of great medicinal importance, and the construction of nitrogen heterocyclic scaffolds has been one of the focuses in synthetic organic chemistry. Recently, the strategy of transition metal-catalyzed sp3 C-H activation and intramolecular C-N coupling to construct nitrogen heterocyclic scaffolds has been well developed. Palladium, copper, silver, nickel, cobalt, ruthenium and rhodium catalysis were successfully used for the construction of nitrogen heterocyclic scaffolds, aziridines, azetidines, pyrrolidines, pyrrolidine-2,5-diones, indolines, isoindolines, isoindolinones, tetrahydropyridines, oxazolidinones, oxazinanones, β-lactams, γ-lactams etc., which have been synthesized by the sp3 C-H activation strategy. Here, we summarize the progress of transition metal-catalyzed sp3 C-H activation/intramolecular C-N bond formation, and introduce both the reaction development and mechanisms in numerous synthetically useful intramolecular sp3 C-H catalytic aminations/amidations.
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