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MicroRNA delivery through nanoparticles

Sharon Wei Ling Lee1, Camilla Paoletti2, Marco Campisi2

  • 1Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca Degli Abruzzi 24, 10129 Torino, Italy; Singapore-MIT Alliance for Research & Technology (SMART), BioSystems and Micromechanics (BioSyM), Singapore, Singapore(3); Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore(3); Singapore Immunology Network (SIgN), Agency for Science, Technology, and Research, Singapore, Singapore(3).

Journal of Controlled Release : Official Journal of the Controlled Release Society
|October 18, 2019
PubMed

Insights

Nanoparticles offer targeted delivery for microRNA (miRNA) therapeutics, crucial for treating diseases like cancer and neurodegenerative disorders. This review explores nanocarrier design and applications for advancing miRNA-based personalized medicine.

Area of Science:

  • Biomedical Engineering
  • Molecular Biology
  • Nanotechnology

Background:

  • MicroRNAs (miRNAs) play a key role in the development of major diseases.
  • Nanoparticle carriers enable precise, cell-specific delivery of therapeutic miRNAs.

Purpose of the Study:

  • To critically review the application of nanoparticles for miRNA delivery in cancer, neurodegenerative disorders, and tissue regeneration.
  • To provide a new perspective on nanocarrier design and characterization for clinical translation.
  • To discuss challenges and highlight applications of miRNA-nanoparticles for personalized medicine.

Main Methods:

  • Literature review of nanoparticle-based miRNA delivery systems.
  • Analysis of nanocarrier design principles and characterization techniques.
  • Case study analysis of therapeutic applications in oncology, neurology, and regenerative medicine.

Main Results:

  • Nanoparticles show significant potential for targeted miRNA delivery in various disease models.
  • Effective nanocarrier design and characterization are crucial for successful clinical translation.
  • Engineering challenges in miRNA-loaded nanoparticles require innovative solutions.

Conclusions:

  • Nanoparticle-mediated miRNA delivery holds great promise for effective and personalized therapeutic strategies.
  • Further research into nanocarrier engineering is essential to overcome current limitations.
  • This approach could revolutionize the treatment of complex diseases.
Keywords:
BiomaterialsMicroRNA delivery and releaseNanoparticlesPersonalized medicinePhysicochemical characterization

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