Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship01:29

Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship

866
Indirect-acting cholinergic agonists are agents that interact with the acetylcholinesterase enzyme in the synaptic cleft, preventing the breakdown of acetylcholine into choline and acetate. Consequently, the concentration of acetylcholine in the synaptic cleft increases. These agonists can be classified into reversible and irreversible inhibitors based on their duration of action.
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
866
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

5.5K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.5K
Prochirality02:05

Prochirality

4.8K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
4.8K
Cancer Prevention02:59

Cancer Prevention

7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
7.6K
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship01:29

Cholinergic Antagonists: Chemistry and Structure-Activity Relationship

2.6K
Cholinergic antagonists bind to cholinergic receptors and limit the effects of acetylcholine and other cholinergic agonists. Based on the specific cholinergic receptor affinity, these antagonists are classified as muscarinic or nicotinic. Anticholinergics interrupt parasympathetic innervations while sympathetic innervations remain uninterrupted. Muscarinic antagonists are also called 'muscarinic antagonists', 'antimuscarinics', or 'parasympatholytics'. Nicotinic...
2.6K
Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

14.7K
Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
14.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Azam et al. Removal of Chromium(III) and Cadmium(II) Heavy Metal Ions from Aqueous Solutions Using Treated Date Seeds: An Eco-Friendly Method. <i>Molecules</i> 2021, <i>26</i>, 3718.

Molecules (Basel, Switzerland)·2026
Same author

Triazine-based corrosion inhibitors: synthesis, significance, and emerging perspectives.

RSC advances·2026
Same author

Development of new quinoline-triazole based hybrids: synthesis, nano-encapsulation, DFT calculations, and evaluation of antidiabetic and antioxidant activity.

RSC advances·2026
Same author

Synthesis, multi-target evaluation and DFT analysis of 6-hydroxychromone derived hydrazones with carbonic anhydrase I-II/acetylcholinesterase inhibition and antioxidant activity.

RSC advances·2026
Same author

Indenoquinoxaline-Based Spiro-Heterocycles: Synthesis, Structural Characterization, MEDT Study, and Dual Inhibition of Kinase-Related Enzymes EGFR and VEGFR2.

Chemistry & biodiversity·2025
Same author

In Vitro and In Silico Assessment of Datura stramonium Flower Alkaloids as Multi-Target Inhibitors of Biofilm Formation, Xanthine Oxidase, and Tyrosinase Enzymes.

Chemistry & biodiversity·2025

Related Experiment Video

Updated: Jan 5, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
05:17

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

1.9K

Anticancer Indole-Based Chalcones: A Structural and Theoretical Analysis.

Farid A Badria1, Saied M Soliman2,3, Saleh Atef4

  • 1Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. faridbadria@gmail.com.

Molecules (Basel, Switzerland)
|October 19, 2019
PubMed
Summary

Five novel N-ethylindole chalcones were synthesized and characterized. Their crystal structures reveal C-H···O bonds and π-stacking interactions, influencing molecular packing and antiproliferative activity.

Keywords:
chalconecrystal structurecytotoxic activityindole

More Related Videos

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
06:34

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

Published on: June 20, 2014

14.3K
A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
07:30

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

8.6K

Related Experiment Videos

Last Updated: Jan 5, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
05:17

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

1.9K
Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
06:34

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

Published on: June 20, 2014

14.3K
A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
07:30

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

8.6K

Area of Science:

  • Organic Chemistry
  • Crystallography
  • Computational Chemistry
  • Medicinal Chemistry

Background:

  • Chalcones are a significant class of organic compounds with diverse biological activities.
  • Indole derivatives are known for their wide range of pharmacological properties.
  • Understanding the structure-activity relationship of novel chalcones is crucial for drug discovery.

Purpose of the Study:

  • To synthesize and characterize five new chalcone derivatives incorporating an N-ethylindole moiety.
  • To investigate the crystal structures and intermolecular interactions of these novel compounds.
  • To evaluate the antiproliferative activity and explore the electronic properties of the synthesized chalcones.

Main Methods:

  • Synthesis of five N-ethylindole-derived chalcones with varying substituents.
  • Single-crystal X-ray diffraction to determine molecular and crystal structures.
  • Hirshfeld surface analysis to quantify intermolecular interactions.
  • Density Functional Theory (DFT) calculations for electronic properties and reactivity indices.

Main Results:

  • The crystal structures of five new chalcones (3a-3e) were successfully determined.
  • Molecular packing is dominated by C-H···O hydrogen bonds, C-H···π, and π···π stacking interactions.
  • DFT calculations provided insights into the polarity order (3b < 3d < 3e < 3a < 3c) and chemical reactivity indices.
  • The antiproliferative activity of the synthesized chalcones was investigated.

Conclusions:

  • The study successfully synthesized and characterized novel N-ethylindole chalcones.
  • Intermolecular interactions play a significant role in the solid-state structure of these compounds.
  • The calculated electronic properties and determined antiproliferative activity provide a basis for further medicinal chemistry exploration.