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Microfluidic Tools for Probing Fungal-Microbial Interactions at the Cellular Level
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Pathogenetic Impact of Bacterial-Fungal Interactions

Filomena Nogueira1,2,3, Shirin Sharghi4,5,6, Karl Kuchler7

  • 1CCRI-St. Anna Children's Cancer Research Institute, Vienna 1090, Austria. filomena.nogueira@ccri.at.

Microorganisms
|October 19, 2019
PubMed

Insights

Polymicrobial infections involving bacteria and fungi present severe clinical challenges and antimicrobial resistance. This review explores over twenty interactions, focusing on immune response and clinical outcomes.

Area of Science:

  • Microbiology
  • Immunology
  • Infectious Diseases

Background:

  • Polymicrobial infections pose significant clinical threats due to severity and antimicrobial resistance.
  • Microbiota balance is crucial for preventing dysbiosis and disease.
  • Bacteria and fungi communicate via signaling molecules, impacting host immunity and treatment efficacy.

Purpose of the Study:

  • To review bacterial-fungal interactions involving clinically important pathogens.
  • To focus on quorum-sensing molecules, immune response, and clinical outcomes.

Main Methods:

  • Literature review of over twenty bacterial-fungal interactions.
  • Analysis of interactions focusing on quorum sensing, immune modulation, and clinical impact.

Main Results:

  • Interactions can be synergistic or antagonistic, observed both in vitro and in vivo.
  • Quorum-sensing molecules play a key role in modulating these interactions.
  • Bacterial-fungal interactions significantly influence host immune responses and treatment outcomes.

Conclusions:

  • Understanding bacterial-fungal interactions is vital for managing polymicrobial infections.
  • Targeting microbial communication and host immune responses may improve treatment strategies.
  • Further research into specific pathogen interactions is warranted to combat clinical challenges.
Keywords:
bacterial–fungal interactionsimmune responsein vivo modelsmicrobiomemolecules

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