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Correction: Kang et al. Fluid Flow to Electricity: Capturing Flow-Induced Vibrations with Micro-Electromechanical-System-Based Piezoelectric Energy Harvester. <i>Micromachines</i> 2024, <i>15</i>, 581.

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Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients
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Microfluidic Technologies for cfDNA Isolation and Analysis.

Zheyun Xu1, Yi Qiao2, Jing Tu3

  • 1State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. xuzheyun95@163.com.

Micromachines
|October 19, 2019
PubMed
Summary
This summary is machine-generated.

Microfluidic technologies offer a promising solution for analyzing cell-free DNA (cfDNA), overcoming challenges like low abundance and fragmentation for improved precision oncology. These advanced lab-on-a-chip devices enable rapid, automated cfDNA isolation and quantification.

Keywords:
LOCcfDNA analysiscfDNA isolationmicrofluidics

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Oncology

Background:

  • Cell-free DNA (cfDNA) is crucial in precision oncology for informing genomic mutations, tumor burden, and drug resistance.
  • Absolute quantification of cfDNA concentration serves as an independent prognostic biomarker for overall survival.
  • Low abundance and high fragmentation of cfDNA present significant challenges for isolation and analysis.

Purpose of the Study:

  • To review existing and potential applications of microfluidic technologies in cfDNA analysis.
  • To highlight how microfluidics can address limitations in cfDNA isolation and quantification.
  • To discuss future perspectives for microfluidic applications in cfDNA-based diagnostics.

Main Methods:

  • Review of current literature on microfluidic technologies for cfDNA.
  • Analysis of microfluidic platforms for sample handling at the micrometer scale.
  • Exploration of automated and high-throughput cfDNA screening methods.

Main Results:

  • Microfluidic and lab-on-a-chip (LOC) devices enable handling of small cfDNA sample volumes.
  • These technologies facilitate rapid cfDNA isolation and potential for simultaneous examination and quantification.
  • Microfluidic platforms offer automation and high-throughput screening, reducing manual liquid transfer.

Conclusions:

  • Microfluidic technologies present a significant opportunity to advance cfDNA isolation, enrichment, and analysis.
  • Further exploration and development of microfluidic applications are needed for comprehensive cfDNA diagnostics.
  • These technologies can enhance precision oncology by enabling more efficient and accurate cfDNA analysis.