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Related Experiment Videos

Structural gene encoding human factor XII is located at 5q33-qter.

N J Royle1, M Nigli, D Cool

  • 1Department of Human Genetics, University of Manitoba, Canada.

Somatic Cell and Molecular Genetics
|March 1, 1988
PubMed
Summary

The human factor XII (F12) gene, also known as Hageman factor, has been successfully mapped to chromosome 5q33-qter. This finding refines our understanding of F12 gene localization in the human genome.

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Area of Science:

  • Human Genetics
  • Molecular Biology
  • Gene Mapping

Background:

  • The precise chromosomal location of the human factor XII (F12) gene was previously uncertain.
  • Factor XII plays a crucial role in the intrinsic pathway of blood coagulation.

Purpose of the Study:

  • To determine the accurate chromosomal location of the human factor XII (F12) gene.
  • To resolve conflicting previous reports on F12 gene localization.

Main Methods:

  • Human-hamster somatic cell hybridization was employed using a cloned F12 gene fragment.
  • In situ hybridization was performed on normal human metaphase chromosomes.

Main Results:

  • The human F12 gene was mapped to chromosome region 5q33-qter.

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  • This study provides definitive localization, correcting prior assignments.

    • Conclusions:

    • The F12 gene is definitively located on chromosome 5q33-qter.
    • This precise mapping is essential for future genetic studies and understanding related disorders.