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Microorganisms in Medicine and Therapeutics

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Smart polymers for cell therapy and precision medicine.

Hung-Jin Huang1, Yu-Liang Tsai1, Shih-Ho Lin1

  • 1Institute of Polymer Science and Engineering, National Taiwan University, No. 1, Sec. 4 Roosevelt Road, Taipei, 10617, Taiwan, Republic of China.

Journal of Biomedical Science
|October 19, 2019
PubMed
Summary

Smart polymers are advanced soft materials for biomedical applications. This review covers their design, characterization, and use in cell/drug delivery, 3D bioprinting, and precision medicine.

Keywords:
BioprintingCell therapyPrecision medicineSmart materialsTissue engineering

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Polymer Science

Background:

  • Soft materials, particularly smart polymers, have seen rapid development in the biomedical field over the last decade.
  • Advances in medical devices, cell therapy, and 3D printing have driven the need for sophisticated biomaterials.
  • Smart polymers offer unique responsive properties crucial for next-generation medical applications.

Purpose of the Study:

  • To review the design principles and characterization techniques for smart polymers.
  • To highlight the current progress in the application of smart polymers in biomedicine.
  • To discuss the existing challenges and future directions for smart polymer development.

Main Methods:

  • Review of existing literature on smart polymers in the biomedical field.
  • Analysis of material design strategies for responsive polymers.
  • Examination of characterization methods for evaluating polymer properties.
  • Synthesis of information on applications such as cell/drug carriers and bioprinting.

Main Results:

  • Thermally-responsive polymers are effective as cell carriers and in 3D printing.
  • Self-healing polymers demonstrate injectability and structural recovery after damage.
  • Shape memory polymers possess the ability to retain their original form.
  • Smart polymers are versatile for cell, drug, and protein delivery systems.

Conclusions:

  • Smart polymers, including thermally-responsive, self-healing, and shape memory types, offer significant potential in precision medicine.
  • Their properties like injectability and shape memory are advantageous for bioprinting and minimally invasive surgery.
  • Further research is needed to overcome current challenges and fully realize the clinical applications of these advanced materials.