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The short arm of chromosome 6 is nonrandomly rearranged in secondary myelodysplastic syndromes
C Mecucci1, J L Michaux, A Louwagie
1Center for Human Genetics, University of Leuven, Belgium.
Cancer Genetics and Cytogenetics
|April 1, 1988
Abstract:
Eight patients with a myelodysplastic syndrome showed a structural rearrangement of the short arm of chromosome #6 involving the distal segment 6p22----6pter. In four cases the myelodysplastic disorder appeared after treatment with chemo- and/or radiotherapy. Cytogenetically, the 6p anomaly was consistently associated with abnormalities of chromosome #5 and/or #7 in seven of eight cases. We believe we identified a new site on 6p that is nonrandomly involved in iatrogenically and possibly also environmentally induced malignant hematologic disorders.