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High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
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Structure Solves the Problem with Malaria Merozoite Vaccines
1Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Trends in Parasitology
|October 19, 2019
Abstract:
Malaria vaccines targeting merozoite invasion of erythrocytes have long held appeal but failed in clinical trials. Three structural studies of antibody-antigen complexes by Alanine et al., Urusova et al., and Rawlinson et al. define neutralizing and nonneutralizing epitopes in essential invasion proteins, leading to rational design of improved merozoite vaccines.

