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Secondary leukemia with a translocation (8;21)?
S V Davies1, J A Murray, S M Bowser-Riley
1Department of Hematology, Selly Oak Hospital, Birmingham, Great Britain.
Cancer Genetics and Cytogenetics
|April 1, 1988
Abstract:
The clinical features and cytogenetic changes of acute myeloid leukemia (AML) developing 10 years after radiotherapy and chemotherapy (for osteosarcoma) are described. Features of both de novo AML [FAB M2 morphology, t(8;21), and "secondary leukemia" (additional cytogenetic changes, resistance to chemotherapy) were present. The importance of differentiation between primary and "therapy-linked" disease, and the difficulties in making such a distinction, are discussed.