Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

Applications Of NMR In Biology

Applications Of NMR In Biology

Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

iPSC Neurodegenerative Disease Initiative isogenic CAG repeat iPSC line for Huntington's disease.

bioRxiv : the preprint server for biology·2026

Same author

R1398 is the GTP-𝛾-phosphate sensor that drives the ROC G-domain switching mechanism unique to Parkinson's disease-associated LRRK2.

Research square·2026

Same author

Is SORL1 a common genetic target across neurodegenerative diseases? A multi-ancestry biobank study.

Brain : a journal of neurology·2026

Same author

The complete genome of the KOLF2.1J reference iPSC line.

bioRxiv : the preprint server for biology·2026

Same author

Sex effects on gene expression across the human cerebral cortex at cell type resolution.

Science (New York, N.Y.)·2026

Same author

Temporal proteomic and phosphoproteomic dynamics during neuronal differentiation in the reference iPSC line KOLF2.1J.

Science signaling·2026

Search research articles

Related Experiment Video

Updated: Jan 5, 2026

Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue

Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue

Published on: August 28, 2021

Proteomics: techniques and applications in neuroscience.

Mark R Cookson¹

¹Laboratory of Neurogenetics, Cell Biology and Gene Expression Section, National Institute on Aging, Bethesda, Maryland, USA.

Journal of Neurochemistry

|October 19, 2019

Summary

This summary is machine-generated.

This special issue explores proteomics techniques for neuroscience applications. It covers using proteome analysis for disease biomarkers in human and model systems, highlighting current utility and future enhancements.

More Related Videos

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

Using Near-infrared Fluorescence and High-resolution Scanning to Measure Protein Expression in the Rodent Brain

Using Near-infrared Fluorescence and High-resolution Scanning to Measure Protein Expression in the Rodent Brain

Published on: May 23, 2019

Related Experiment Videos

Last Updated: Jan 5, 2026

Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue

Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue

Published on: August 28, 2021

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

Using Near-infrared Fluorescence and High-resolution Scanning to Measure Protein Expression in the Rodent Brain

Using Near-infrared Fluorescence and High-resolution Scanning to Measure Protein Expression in the Rodent Brain

Published on: May 23, 2019

Area of Science:

Neuroscience
Biochemistry
Genomics

Background:

Proteomics offers a comprehensive survey of protein content in cells or tissues.
This special issue focuses on the application of proteomics in neuroscience research.

Discussion:

Articles detail the use of proteomics for identifying disease biomarkers in human samples (living and post-mortem).
Applications extend to model systems, including animals and cell cultures.

Key Insights:

Current proteomic technologies are valuable for interrogating the proteome.
The special issue showcases diverse applications of protein analysis in neurological studies.

Outlook:

Future enhancements in protein technologies will shape upcoming proteomic studies.
Continued advancements promise deeper insights into neurological diseases and functions.