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A bivalent antihypertensive vaccine targeting L-type calcium channels and angiotensin AT1 receptors

Hailang Wu1,2,3, Yiyi Wang1,2,3, Gongxin Wang4

  • 1Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

British Journal of Pharmacology
|October 19, 2019
PubMed

Insights

A novel bivalent vaccine targeting angiotensin AT1 receptors and CaV 1.2 channels effectively reduced blood pressure in hypertensive rodents. This immunotherapy demonstrated antihypertensive effects and protected against organ damage without significant adverse effects, offering a promising new hypertension treatment.

Area of Science:

  • Cardiovascular Research
  • Vaccine Development
  • Immunotherapy

Background:

  • Hypertension is a leading global cause of preventable premature death.
  • Novel therapeutic strategies are crucial for effective hypertension management.

Purpose of the Study:

  • To design and evaluate an efficient vaccine for hypertension treatment.
  • To develop a bivalent vaccine targeting angiotensin AT1 receptors and L-type calcium channels (CaV 1.2).

Main Methods:

  • Developed Qβ-CE12 and HBcAg-CE12-CQ10 vaccines using virus-like particles.
  • Conjugated CE12 epitope from CaV 1.2 with Qβ bacteriophage.
  • Evaluated vaccine efficacy in hypertensive rodent models (rats and mice).

Main Results:

  • Qβ-CE12 vaccine reduced blood pressure in hypertensive rodents.
  • Monoclonal antibodies against CE12 inhibited CaV 1.2 channel activity and lowered blood pressure.
  • HBcAg-CE12-CQ10 vaccine demonstrated significant antihypertensive effects and ameliorated renal injury.
  • No significant immune-mediated damage or adverse electrophysiological effects were observed.

Conclusions:

  • Bivalent immunotherapy targeting AT1 receptors and CaV 1.2 channels effectively lowers blood pressure.
  • This approach provides protection against target organ damage in hypertension.
  • The HBcAg-CE12-CQ10 vaccine represents a novel and promising therapeutic strategy for hypertension.
Abstract

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