Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

2.2K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hierarchical sensory processing in zebrafish thalamocortical-like circuits.

Science (New York, N.Y.)·2026
Same author

Experience-dependent modulation of collective behavior in larval zebrafish.

Nature communications·2026
Same author

Reply to "Correspondence: Androgen receptor mRNA in glioblastoma: a reliable marker of tumor burden or a statistical artefact?"

Molecular biology reports·2026
Same author

Artificial light pollution disrupts sleep and neuronal genomic stability in wild reef fish.

Current biology : CB·2026
Same author

Efficacy and stability of maxillary arch expansion with clear aligners versus conventional slow maxillary expanders in growing patients: A multicenter prospective cohort study.

Korean journal of orthodontics·2026
Same author

Whole-body 3D kinematics of freely behaving <i>Drosophila</i>.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jan 5, 2026

High-fat Feeding Paradigm for Larval Zebrafish: Feeding, Live Imaging, and Quantification of Food Intake
11:30

High-fat Feeding Paradigm for Larval Zebrafish: Feeding, Live Imaging, and Quantification of Food Intake

Published on: October 27, 2016

11.0K

A bidirectional network for appetite control in larval zebrafish.

Caroline Lei Wee1,2, Erin Yue Song1, Robert Evan Johnson1,2

  • 1Department of Molecular and Cell Biology, Harvard University, Cambridge, United States.

Elife
|October 19, 2019
PubMed
Summary

In larval zebrafish, the caudal hypothalamus (cH) and lateral hypothalamus (LH) exhibit opposing neural activity patterns during feeding and fasting. This antagonistic interaction regulates hunger, satiety, and energy balance.

Keywords:
appetitehypothalamusneuroscienceserotoninzebrafish

More Related Videos

Microgavage of Zebrafish Larvae
10:53

Microgavage of Zebrafish Larvae

Published on: February 20, 2013

17.8K
Combining Quantitative Food-intake Assays and Forcibly Activating Neurons to Study Appetite in Drosophila
07:24

Combining Quantitative Food-intake Assays and Forcibly Activating Neurons to Study Appetite in Drosophila

Published on: April 24, 2018

8.7K

Related Experiment Videos

Last Updated: Jan 5, 2026

High-fat Feeding Paradigm for Larval Zebrafish: Feeding, Live Imaging, and Quantification of Food Intake
11:30

High-fat Feeding Paradigm for Larval Zebrafish: Feeding, Live Imaging, and Quantification of Food Intake

Published on: October 27, 2016

11.0K
Microgavage of Zebrafish Larvae
10:53

Microgavage of Zebrafish Larvae

Published on: February 20, 2013

17.8K
Combining Quantitative Food-intake Assays and Forcibly Activating Neurons to Study Appetite in Drosophila
07:24

Combining Quantitative Food-intake Assays and Forcibly Activating Neurons to Study Appetite in Drosophila

Published on: April 24, 2018

8.7K

Area of Science:

  • Neuroscience
  • Neuroendocrinology
  • Behavioral Biology

Background:

  • The medial and lateral hypothalamus are recognized for their roles in appetite suppression and enhancement, respectively.
  • The dynamic interplay and functional significance of these hypothalamic regions in regulating feeding behavior remain underexplored.

Purpose of the Study:

  • To investigate the interaction between hypothalamic nuclei during feeding and fasting states.
  • To elucidate the functional significance of these interactions in regulating energy balance and feeding behavior.

Main Methods:

  • Monitoring neural activity in the caudal hypothalamus (cH) and lateral hypothalamus (LH) of larval zebrafish during food deprivation and refeeding.
  • Utilizing food sensory and consummatory cues to observe changes in hypothalamic activity.
  • Employing targeted stimulation and ablation of cH neurons to confirm functional relationships.

Main Results:

  • Food deprivation increased activity in serotonergic neurons of the ventromedial caudal hypothalamus (cH) and decreased activity in the lateral hypothalamus (LH).
  • Exposure to food cues reversed these activity patterns, aligning with opposing internal hunger states.
  • Baseline activity was restored upon refeeding and return to satiety.

Conclusions:

  • The caudal hypothalamus (cH) and lateral hypothalamus (LH) exhibit antagonistic activity patterns that are crucial for regulating hunger and satiety.
  • These hypothalamic nuclei coordinate energy balance through the antagonistic control of distinct behavioral outputs.
  • A model is proposed where cH and LH neurons regulate different phases of hunger and satiety.