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Associations between miR-146a rs2910164 polymorphisms and risk of ischemic cardio-cerebrovascular diseases

Dongdong Zhao1, Yuerong Li1, Xiuyan Yu1

  • 1Department of Cardiology, The Affiliated Hospital of Binzhou Medical University, Binzhou.

Medicine
|October 19, 2019
PubMed

Insights

The miR-146a rs2910164 polymorphism is linked to a reduced risk of ischemic cardio-cerebrovascular diseases, particularly coronary heart disease. This genetic variant may serve as a valuable predictor for disease susceptibility.

Area of Science:

  • Genetics
  • Cardiovascular Epidemiology
  • Molecular Biology

Background:

  • Previous studies explored the link between miR-146a rs2910164 polymorphisms and ischemic cardio-cerebrovascular disease risk.
  • Existing research findings on this association remain inconsistent.

Purpose of the Study:

  • To conduct a comprehensive meta-analysis evaluating the relationship between miR-146a rs2910164 polymorphisms and the risk of ischemic cardio-cerebrovascular diseases.
  • To clarify the inconsistent findings from previous individual studies.

Main Methods:

  • A systematic literature search was performed across multiple databases (PubMed, EMBASE, Cochrane Library, Web of Science, CNKI, VIP, Wanfang).
  • Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of associations.
  • Statistical analyses included heterogeneity, sensitivity, and publication bias assessments to ensure robustness.

Main Results:

  • The meta-analysis included 26 studies with 11,602 cases and 14,016 controls.
  • miR-146a rs2910164 polymorphisms were significantly associated with a reduced risk of coronary heart disease (CHD) across all genetic models.
  • A reduced risk of ischemic cardio-cerebrovascular diseases was also observed in subgroup analyses of large sample sizes.

Conclusions:

  • miR-146a rs2910164 polymorphisms are significantly associated with a lower risk of ischemic cardio-cerebrovascular diseases.
  • This specific polymorphism may be a potential predictive marker for susceptibility to these vascular conditions.
Abstract

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