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[Stroke and depression].

Yu P Sivolap1, I V Damulin1

  • 1Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|October 19, 2019
PubMed
Summary

Post-stroke depression is common and worsens outcomes. Antidepressants effectively treat depression, improving neurological function, quality of life, and survival rates in stroke patients.

Keywords:
antidepressantsmortalityoutcomepost-stroke depressionselective serotonin reuptake inhibitorsstroke

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Area of Science:

  • Neurology
  • Psychiatry
  • Clinical Medicine

Background:

  • Depression is a common complication after stroke, affecting about one in three survivors.
  • Post-stroke depression significantly worsens neurological outcomes, physical function, quality of life, and increases mortality risk.
  • It also reduces the effectiveness of rehabilitation and therapeutic interventions.

Purpose of the Study:

  • To review the impact of depression on stroke recovery.
  • To evaluate the efficacy of antidepressants in managing post-stroke depression.
  • To identify areas for future research in treating depression in stroke patients.

Main Methods:

  • Literature review of studies on post-stroke depression and antidepressant treatment.
  • Analysis of the effects of depression on neurological recovery and patient outcomes.
  • Evaluation of different classes of antidepressants, including selective serotonin reuptake inhibitors (SSRIs) and tricyclic drugs.

Main Results:

  • Antidepressants are effective in alleviating depressive symptoms, mitigating neurological deficits, and improving cognitive function in post-stroke patients.
  • Treatment with antidepressants enhances the effectiveness of rehabilitation, improves overall patient condition, and reduces the risk of recurrent stroke and death.
  • Selective serotonin reuptake inhibitors (SSRIs) are considered first-line treatment, with evidence supporting other modern antidepressants and tricyclic drugs.

Conclusions:

  • Antidepressant therapy is crucial for managing depression after stroke, leading to improved functional recovery and survival.
  • Further research is needed on the tolerability in elderly patients, optimal drug selection, and therapy duration.
  • Addressing post-stroke depression is essential for optimizing patient outcomes and reducing healthcare burden.