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Updated: Jan 5, 2026

Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy
Published on: September 5, 2016
HIV-1 Replication Benefits from the RNA Epitranscriptomic Code
Weili Kong1, Efraín E Rivera-Serrano2, Jason A Neidleman3
1Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA; Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA, 94158, USA.
Abstract:
The effects of RNA methylation on HIV-1 replication remain largely unknown. Recent studies have discovered new insights into the effect of 2'-O-methylation and 5-methylcytidine marks on the HIV-1 RNA genome. As so far, HIV-1 benefits from diverse RNA methylations through distinct mechanisms. In this review, we summarize the recent advances in this emerging field and discuss the role of RNA methylation writers and readers in HIV-1 infection, which may help to find alternative strategies to control HIV-1 infection.
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