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Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
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Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
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Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

872
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Other Pulmonary Disorders01:17

Other Pulmonary Disorders

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Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
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Updated: Jan 5, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
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Tuberculosis control in crisis-causes and solutions.

Gilla Kaplan1

  • 1University of Cape Town, Cape Town, South Africa.

Progress in Biophysics and Molecular Biology
|October 19, 2019
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Global tuberculosis control efforts are failing to meet targets due to significant patient care gaps. Diagnosing and reporting missing tuberculosis patients, alongside developing new tools, is crucial for accelerating progress.

Keywords:
Global epidemicMultidrug resistant tuberculosisPatient pathway analysisTuberculosisTuberculosis control

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The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
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Area of Science:

  • Global Health
  • Infectious Diseases
  • Public Health Policy

Background:

  • Tuberculosis (TB) incidence decline is insufficient to meet UN targets.
  • Patient-pathway analysis reveals critical gaps in TB care cascade.
  • Failure to diagnose and report TB patients is a major global challenge.

Purpose of the Study:

  • To identify reasons for slow progress in global TB control.
  • To prioritize strategies for finding "missing" TB patients.
  • To highlight the need for new tools and improved service delivery.

Main Methods:

  • Patient-pathway analysis supported by the Bill and Melinda Gates Foundation.
  • Identification of commonalities and country-specific reasons for care gaps.
  • Assessment of current TB control tools and research needs.

Main Results:

  • Significant patient loss observed across the entire TB care cascade.
  • Failure in TB diagnosis and reporting identified as a critical bottleneck.
  • Existing tools alone are insufficient to accelerate TB incidence decline.

Conclusions:

  • Finding "missing" TB patients is a global priority.
  • Development of novel diagnostics, treatments, and vaccines is essential.
  • Sustained government commitment to research and service delivery is required to end TB.