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Prediction of tablet weight variability in continuous manufacturing.

Sonia M Razavi1, James Scicolone1, Ronald D Snee2

  • 1Engineering Research Center for Structured Organic Particulate Systems (C-SOPS), Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

International Journal of Pharmaceutics
|October 19, 2019
PubMed
Summary

Predict tablet weight variability in direct compaction continuous manufacturing. Key material attributes like cohesion, bulk density, and particle size significantly impact tablet weight consistency.

Keywords:
Continuous manufacturingDirect compactionMaterial attributesProcess parametersQuality-by-design (QbD)Tablet weight variabilityTableting

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