Analysis of 5000 year-old human teeth using optimized large-scale and targeted proteomics approaches for detection of
Carine Froment1, Mathilde Hourset2, Nancy Sáenz-Oyhéréguy3
1Institut de Pharmacologie et Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France.
Journal of Proteomics
|October 19, 2019
Abstract:
The study demonstrates the high potential of MS-based proteomics coupled to an iterative database search strategy for the in-depth investigation of ancient proteomes. An efficient targeted PRM MS-based approach, although limited to the detection of a single pair of sex-specific amelogenin peptides, allowed confirming the sex of individuals in ancient dental remains, an essential information for paleoanthropologists facing the issue of sex determination and dimorphism.
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