[Replacement therapy for hypothyroidism with thyroid hormonal drugs: one or two hormones?]

In recent years, along with a large number of works devoted to the problem of subclinical hypothyroidism, the first studies have appeared that raise the problem that was actively discussed in the 70s at the current methodological level - what is the place of L-T3 drugs in hypothyroidism replacement therapy, and does monotherapy L -T4 advantages over combination treatment. Over the past few years, publications have appeared in the literature in which the authors, citing their own clinical experience in the treatment of patients with hypothyroidism, speak out in favor of the combination therapy of L-T3 and L-T4. This review is devoted to a comprehensive analysis of research results in this area.