Related Experiment Video

Updated: Jan 5, 2026

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

11.9K

[Platelet membrane pathology in vascular complications of type 1 diabetes mellitus]

Y В Kravets1, N V Ryazantseva1, N M Yakovleva1

  • 1Siberian State Medical University.

Problemy Endokrinologii
|October 20, 2019
PubMed

Insights

Platelet membrane dysfunction in type 1 diabetes mellitus (DM) contributes to vascular complications. These impairments worsen with disease severity and decompensation, suggesting therapeutic targets.

Area of Science:

  • Biochemistry
  • Pathophysiology
  • Hematology

Context:

  • Type 1 diabetes mellitus (DM) is associated with significant vascular complications.
  • Diabetic microangiopathies affect small blood vessels, leading to conditions like retinopathy and nephropathy.
  • Platelet function is increasingly recognized as a factor in diabetic vascular disease.

Purpose:

  • To investigate the role of platelet membrane structural and functional changes in the development of vascular complications in type 1 DM.
  • To correlate the degree of platelet membrane impairment with the severity of diabetic retinopathy and nephropathy.
  • To understand the pathogenetic basis of altered blood cell microrheology in diabetic microangiopathies.

Summary:

  • Seventy-seven patients with type 1 DM (ages 18-55) and varying stages of retinopathy and nephropathy were studied.
  • Patients exhibited significant platelet membrane structural and functional alterations, including increased lipid phase microviscosity and inhibited Na+,K+-ATPase activity.
  • These platelet impairments were found to correlate with the extent of vascular complications and were most pronounced during DM decompensation.

Impact:

  • Identifies specific platelet membrane dysfunctions (e.g., altered microviscosity, enzyme activity) as key contributors to vascular complications in type 1 DM.
  • Highlights the correlation between the severity of platelet impairment and the progression of diabetic retinopathy and nephropathy.
  • Suggests that understanding these pathogenetic mechanisms may enable the use of membrane-stabilizing agents for therapeutic intervention in diabetic microangiopathies.

Keywords:
Na+/K+-ATPase activityangiopathiesfluorescence probinglipoic acidmembraneplateletsulodexidetype 1 diabetes mellitus

More Related Videos

An Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy08:10

An Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy

Published on: January 25, 2019

8.2K
Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies07:06

Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies

Published on: January 10, 2025

1.1K

Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
274
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.0K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
8.5K
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.9K
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
236
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
2.8K