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Updated: Jan 5, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
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[Diagnosis of insulin resistance in children and adolescents]

A V Vitebskaya1, O V Vasyukova1

  • 1Endocrinology Research Centre.

Problemy Endokrinologii
|October 20, 2019
PubMed

Insights

Childhood obesity contributes to metabolic syndrome and related diseases. Insulin resistance is a key factor in metabolic syndrome development in children and adults.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Metabolic Diseases

Context:

  • Childhood obesity is a growing global health concern.
  • Obesity in children is linked to increased metabolic syndrome risk.
  • Metabolic syndrome is a cluster of conditions that increase the risk of heart disease, stroke, and type 2 diabetes.

Purpose:

  • To highlight the connection between childhood obesity and metabolic syndrome.
  • To explain the role of insulin resistance in metabolic syndrome.
  • To underscore the importance of addressing childhood obesity to prevent metabolic diseases.

Summary:

  • High prevalence of childhood obesity is a significant factor in the rising incidence of metabolic syndrome.
  • Insulin resistance, a disruption in insulin's biological effects on tissues, is central to metabolic syndrome development.
  • This resistance occurs at pre-, post-, and receptor levels, impacting how tissues respond to insulin.

Impact:

  • Understanding this link is crucial for developing effective prevention and treatment strategies for metabolic syndrome in pediatric populations.
  • Early intervention can mitigate long-term health consequences associated with metabolic syndrome.
  • Research emphasizes the need for public health initiatives targeting childhood obesity and metabolic health.

Keywords:
childreninsulin resistanceobesity

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