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Related Experiment Videos

Fever in systemic lupus erythematosus.

N I Stahl, J H Klippel, J L Decker

    The American Journal of Medicine
    |December 1, 1979
    PubMed
    Summary

    Febrile episodes in hospitalized lupus patients are often due to lupus activity or infections. Infection, particularly bacteremia, can lead to fatal outcomes in systemic lupus erythematosus patients.

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    Area of Science:

    • Rheumatology
    • Infectious Diseases
    • Internal Medicine

    Background:

    • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
    • Febrile episodes are common in SLE patients, necessitating differentiation between disease flares and infections.
    • Understanding the causes and predictors of fever in SLE is crucial for patient management.

    Purpose of the Study:

    • To determine the frequency, causes, clinical features, and outcomes of febrile episodes in hospitalized patients with SLE.
    • To identify factors associated with infection in febrile SLE patients.

    Main Methods:

    • Retrospective review of 160 hospitalized patients with SLE.
    • Analysis of 83 febrile episodes, categorizing causes as active SLE, infection, or miscellaneous.
    • Correlation of clinical and laboratory findings with infectious causes.

    Main Results:

    • Febrile episodes occurred in 63 patients, with 60% attributed to active SLE, 23% to infections, and 17% to other causes.
    • Bacteremia was present in 9 of 19 infectious episodes, with a one-third mortality rate.
    • Leukocytosis, neutrophilia, shaking chills, and normal anti-DNA antibody levels were associated with infection.

    Conclusions:

    • Infections are a significant cause of fever in hospitalized SLE patients and are associated with increased mortality.
    • Clinical and laboratory markers can help differentiate infection from SLE flares in febrile patients.
    • Prompt diagnosis and management of infections are critical in this vulnerable population.

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