Self-calibrating wave-encoded 3D turbo spin echo imaging using subspace model based autofocusing

To develop a self-calibrating approach for the estimation of wave point spread function (PSF) and coil sensitivities from the subsampled wave-encoded k-space, and evaluate its performance for wave-encoded 3D turbo spin echo (TSE) imaging.

A low rank subspace parametric model was demonstrated in simulation to improve the representation for practical wave encoding k-space trajectories with aperiodicity, and an autofocus metric for the entire imaging volume was used to calibrate the wave PSF in a 2-stage manner from coarse to refined estimation. The coil sensitivities can be extracted from the shifted central region of wave PSF corrected subsampled k-space, and further used with wave PSF for wave-encoded parallel imaging (PI) reconstruction. The wave encoding gradients were integrated into the 3D TSE sequence considering eddy current reduction aspects and maintaining of the Carr-Purcell-Meiboom-Gill condition. Phantom and in vivo brain experiments were performed to evaluate the accuracy of wave PSF self-calibration and to compare the PI reconstruction performance between wave and Cartesian encoding scheme.

The self-calibrated wave PSF, estimated from different k-space undersampling patterns can robustly correct the wave encoding induced image artifacts given sufficient central autocalibration data. The self-calibrating wave-encoded PI reconstruction has demonstrated its improved performance in reduced aliasing artifacts and noise amplification in comparison to the Cartesian-encoded PI reconstruction results for 3D TSE imaging.

The proposed self-calibrating wave-encoded method allows robust calibration of wave PSF and coil sensitivities from the subsampled k-space, and improves the overall image quality for accelerated 3D TSE imaging.