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Direct demonstration of production of transforming growth factor activity by embryonic chick tissue
J C McLachlan1, J Macintyre, D D Hume
1Department of Biology and Preclinical Medicine, University of St. Andrews, Scotland.
Experientia
|April 15, 1988
Abstract:
The presence of transforming growth factor activity in early chick embryos was directly demonstrated by the ability of limb and tail buds to induce anchorage independent division in NRK 49 f cells. Colony number increased with limb bud number and developmental stage. Medium conditioned by tail buds contained some stimulating effect, and strongly promoted the action of other transforming growth factors.