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Enoxacin distribution in human tissues after multiple oral administration
1Department of Clinical Microbiology, Huddinge University Hospital, Karolinska Institute, Sweden.
The Journal of Antimicrobial Chemotherapy
|February 1, 1988
Summary
Enoxacin effectively penetrates various tissues, with higher concentrations found in renal cortex, medulla, and muscle compared to serum. This suggests potential efficacy for treating skin, soft tissue, and urinary tract infections.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Infectious Diseases
Background:
- Enoxacin is a fluoroquinolone antibiotic with broad-spectrum activity.
- Understanding tissue penetration is crucial for optimizing antibiotic efficacy and dosing.
Purpose of the Study:
- To determine the tissue distribution and urinary excretion of enoxacin in patients undergoing nephrectomy.
- To evaluate the potential therapeutic effectiveness of enoxacin based on its tissue concentrations.
Main Methods:
- Six patients received oral enoxacin (200 mg twice daily for three days preoperatively).
- Tissue samples (blood, skin, fat, muscle, bone, kidney) and urine were collected during surgery.
- Enoxacin concentrations were measured using an agar-well diffusion method.
Main Results:
- Mean 24-hour urinary excretion was 62.7% of the daily dose.
- Concentrations in renal cortex (ratio 3.8), medulla (3.2), and muscle (1.4) exceeded serum levels.
- Skin (0.8) and fat (0.2) showed lower concentrations; bone levels were often undetectable.
Conclusions:
- Enoxacin demonstrates favorable penetration into renal and muscle tissues.
- The drug's pharmacokinetic profile supports its potential use in treating skin, soft tissue, and urinary tract infections.
- Further studies may refine dosing strategies for optimal therapeutic outcomes.