Enhancing cutaneous delivery with laser technology: Almost there, but not yet

Area of Science:

• Biomedical Engineering
• Dermatology
• Drug Delivery Systems

Background:

• The stratum corneum presents a significant barrier to effective cutaneous drug delivery.
• Laser-based strategies, including direct ablation, photothermolysis, and mechanical waves, show promise for overcoming this barrier.
• Standardized protocols for routine clinical application of laser-assisted drug delivery are currently lacking.

Purpose of the Study:

• To review the translational potential of various laser technologies for enhancing drug penetration.
• To comparatively analyze preclinical and clinical research on laser-assisted delivery of small molecules and biologics.
• To present future perspectives on laser technological developments in the context of the global laser market.

Main Methods:

• Comparative analysis of preclinical research data on laser-assisted drug delivery.
• Evaluation of clinical-level studies investigating laser-enhanced penetration of pharmaceuticals.
• Review of current trends and future projections in the global laser technology market.

Main Results:

• Preclinical studies demonstrate the efficacy of laser strategies in facilitating the cutaneous delivery of both small molecules and biologics.
• Translation of these laser-assisted drug delivery strategies to clinical settings is progressing but requires further protocol standardization.
• Ongoing advancements in laser technology offer promising avenues for improved drug penetration and therapeutic outcomes.

Conclusions:

• Laser-based approaches offer a viable method for enhancing transdermal drug delivery, with potential for both conventional and novel therapeutics.
• Bridging the gap between preclinical findings and routine clinical application necessitates further research and protocol refinement.
• The evolution of laser technology is expected to drive innovation in minimally invasive drug delivery systems.