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Primary hypothyroidism due to leukemic infiltration of the thyroid gland
V Foresti1, E Parisio, N Scolari
1Ospedale Fatebenefratelli-Oftalmico, III Divisione di Medicina, Milano, Italy.
Journal of Endocrinological Investigation
|January 1, 1988
Abstract:
We describe a patient with acute B-lymphocyte lymphoblastic leukemia who developed laboratory changes (not detectable free thyroxine, TSH 66 microIU/ml) suggesting severe primary hypothyroidism. Histological examination at autopsy showed massive leukemic infiltration of the thyroid gland: the progressive reduction of thyroid hormone levels with concomitant increase in TSH levels observed over a three-month period from the onset of the hemopathy suggests a cause-effect relationship between leukemic infiltration of the thyroid gland and hypothyroidism.