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Updated: Jan 5, 2026
Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
Published on: August 25, 2022
What clinical practice strategies have been shown to decrease incidence rates of intraventricular haemorrhage in
Alexander Howes1, Cathie Hilditch1,2,3, Amy Keir1,2,3,4
1Department of Neonatal Medicine, Women's and Children's Hospital, Adelaide, South Australia, Australia.
Insights
Antenatal corticosteroids and neonatal unit intervention bundles can decrease intraventricular haemorrhage (IVH) rates in preterm infants. These strategies offer evidence-based approaches for neonatal care to improve outcomes.
Area of Science:
- Neonatal Medicine
- Pediatric Neurology
- Clinical Practice Guidelines
Background:
- Intraventricular haemorrhage (IVH) is a significant concern in preterm infants.
- Effective clinical strategies are needed to reduce IVH incidence in neonatal units.
Purpose of the Study:
- To identify clinical practice strategies that decrease intraventricular haemorrhage (IVH) rates in infants admitted to neonatal units.
- To compare the efficacy of these strategies against standard care.
Main Methods:
- Systematic literature search of MEDLINE, Embase, and Cochrane Library databases.
- Screening of 478 articles by title and abstract, followed by full-text review of 40 articles.
- Inclusion of 19 relevant articles and one additional article based on expert recommendation.
Main Results:
- Evidence supports antenatal corticosteroids in reducing IVH rates.
- Multiple evidence-based intervention bundles implemented in neonatal units are associated with decreased IVH incidence.
- Various levels of research evidence exist for different clinical practice strategies.
Conclusions:
- Antenatal corticosteroids represent a high-quality evidence strategy for IVH prevention.
- Implementing comprehensive intervention bundles in neonatal units is effective in lowering IVH rates.
- Further research may refine evidence-based practices for neonatal care and IVH reduction.
Aim:
To answer the clinical question 'In infants about to be delivered and admitted to neonatal units, what clinical practice strategies, compared to standard care, have been shown to decrease incidence rates of intraventricular haemorrhage (IVH)?'
Methods:
MEDLINE via Ovid (1943 to 5 January 2018), Embase via Ovid (1974 to 5 January 2018) and the Cochrane Library (5 January 2018) were searched for relevant articles.
Results:
A total of 478 articles, after the removal of duplicates, were found and screened by title and abstract. Forty full-text articles were subsequently reviewed, and 19 were included as relevant to the structured clinical question. An additional article was included based on expert advice.
Conclusion:
There are various levels of research evidence for clinical practice strategies to decrease the incidence rates of IVH. Higher-quality evidence suggests that antenatal corticosteroids decrease the rates of IVH, and multiple evidence-based intervention bundles implemented in the neonatal unit are associated with decreased rates of IVH.
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