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Polygenic Risk Scores for Developmental Disorders, Neuromotor Functioning During Infancy, and Autistic Traits in

Fadila Serdarevic1, Henning Tiemeier2, Philip R Jansen3

  • 1Generation R Study Group, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Child and Adolescent Psychiatry, Erasmus Medical Center-Sophia Children's Hospital Rotterdam, Rotterdam, The Netherlands; Department of Pediatrics, New York University School of Medicine, New York, New York.

Biological Psychiatry
|October 21, 2019
PubMed

Insights

Genetic predisposition to autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) is linked to impaired infant neuromotor development. Shared genetic factors may explain the connection between early motor difficulties and later autistic traits.

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Psychology

Background:

  • Impaired neuromotor development is an early indicator in children with autism spectrum disorder (ASD).
  • Investigating the genetic basis of developmental disorders and their link to infant neuromotor function is crucial.

Purpose of the Study:

  • To determine if a genetic predisposition for developmental disorders correlates with nonoptimal infant neuromotor development.
  • To examine the genetic correlation between neuromotor development and autistic traits in the general population.

Main Methods:

  • Utilized polygenic risk scores (PRSs) for ASD and ADHD in a Dutch population-based cohort.
  • Assessed infant neuromotor development (9-20 weeks) and autistic traits at 6 years.
  • Employed linear regressions and bivariate genome-based restricted maximum likelihood analyses.

Main Results:

  • Higher PRSs for ASD were associated with less optimal infant neuromotor development, particularly low muscle tone.
  • Higher PRSs for ADHD were linked to impaired sensory development in infants.
  • Both ASD and ADHD PRSs correlated with autistic traits; significant genetic correlation found between motor development and autistic traits.

Conclusions:

  • Genetic liabilities for ASD and ADHD are associated with infant neuromotor development.
  • Shared genetic factors may contribute to the link between early neuromotor issues and childhood autistic traits.
Abstract

Keywords:
ADHDAutismCohortInfantNeuromotorPolygenic risk scorePopulation based

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