What Do International Guidelines Say About First-line Therapy for Clear-cell Metastatic Renal Cell Carcinoma?

Treatment options for clear-cell metastatic renal cell carcinoma (mRCC) have increased significantly. Clinical practice guidelines aim to aid with decision-making about treatment selection through evidence-based recommendations. In this article, recommendations on first-line treatment for clear-cell mRCC in guidelines from three international organizations are reviewed and summarized. Future guideline development should focus on dynamic updates based on practice-changing data and guidance regarding therapy selection. PATIENT SUMMARY: International guidelines for first-line treatment of metastatic renal cell carcinoma are reviewed in this article. The main differences between guidelines appear to be how quickly the newest evidence is included.