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Updated: Jan 5, 2026

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
Gut bacteria characteristic of the infant microbiota down-regulate inflammatory transcriptional responses in
Siva Gowri Pathmanathan1, Blair Lawley2, Michelle McConnell2
1Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand; Department of Medical Sciences, Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia (USIM), Kuala Lumpur, Malaysia.
Abstract:
Immuno-modulatory effects of infant gut bacteria were tested on poly(I:C) stimulated HT-29 intestinal epithelial cells. Blautia producta, Bacteroides vulgatus, Bacteroides fragilis and Bacteroides thetaiotaomicron decreased transcription of poly(I:C)-induced inflammatory genes. Modulation of basal level and poly(I:C)-induced IL-8 secretion varied between bacterial species, and between heat treated and non-heat treated bacterial cells.
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