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Updated: Jan 5, 2026
11:19
Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1
Published on: September 26, 2015
8.4K
DNA Methylation Age and Physical and Cognitive Aging
Jane Maddock1,2, Juan Castillo-Fernandez3, Andrew Wong1
1MRC Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Science, University College London, UK.
Summary
Second-generation DNA methylation age acceleration measures (AgeAccelPheno, AgeAccelGrim) correlate with physical and cognitive function, potentially indicating healthspan. First-generation measures showed limited associations with performance decline.
Area of Science:
- Epigenetics
- Gerontology
- Biomarkers of Aging
Background:
- DNA methylation age acceleration (AgeAccel) predicts mortality, but its functional link to aging is unclear.
- This study investigates AgeAccel's relationship with physical and cognitive performance and age-related decline.
Purpose of the Study:
- To determine which DNAm age acceleration measures correlate with physical and cognitive performance.
- To assess if these measures predict age-related decline in performance.
Main Methods:
- Four AgeAccel measures (Hannum, Horvath, Pheno, Grim) were calculated in three UK cohorts (NSHD, NCDS, TwinsUK).
- Physical (grip strength, chair rise, FEV1) and cognitive (memory, speed) performance were assessed.
- Associations were analyzed using meta-analyses and linear mixed models.
Main Results:
- AgeAccelPheno and AgeAccelGrim, unlike Hannum and Horvath, were associated with physical and cognitive performance.
- Increased AgeAccelPheno/Grim correlated with lower FEV1.
- In NSHD, AgeAccelPheno/Grim at 53 predicted performance decline between 53-69 years.
Conclusions:
- First-generation DNAm biomarkers showed limited association with midlife physical/cognitive performance.
- Second-generation biomarkers (AgeAccelPheno, AgeAccelGrim) show promise as indicators of healthspan.
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