Related Experiment Video
Updated: Jan 5, 2026

11:34
Breathing-controlled Electrical Stimulation BreEStim for Management of Neuropathic Pain and Spasticity
Published on: January 10, 2013
23.6K
Acupuncture/Electroacupuncture as an Alternative in Current Opioid Crisis
Usman Ali1, Evhy Apryani1, Muhammad Zaeem Ahsan1
1King's Lab, Shanghai Jiao Tong University School of Pharmacy, Shanghai, 200240, China.
Chinese Journal of Integrative Medicine
|October 21, 2019
Summary
Electroacupuncture, a Chinese medicine therapy, offers effective pain relief by releasing natural pain-killing opioid peptides. This approach presents a viable alternative for managing the global opioid crisis.
Area of Science:
- Neuroscience
- Pain Management
- Traditional Chinese Medicine
Background:
- Opioid medications are primary treatments for severe pain but pose significant global health risks due to adverse effects.
- The opioid crisis remains a critical worldwide concern, necessitating alternative pain management strategies.
Purpose of the Study:
- To explore electroacupuncture as a potential alternative to opioid analgesics.
- To investigate the mechanism of electroacupuncture in pain relief through endogenous opioid peptide release.
Main Methods:
- Review of existing animal and human studies on acupuncture and electroacupuncture for pain relief.
- Analysis of the physiological pathways involved in electroacupuncture-induced analgesia.
Main Results:
- Electroacupuncture is a well-documented analgesic therapy in both animal and human research.
- Electroacupuncture stimulation triggers the release of endogenous opioid peptides, mediating pain relief across various pain models.
Conclusions:
- Electroacupuncture serves as an effective analgesic therapy with potential to mitigate the adverse effects associated with opioid drugs.
- This traditional Chinese medicine technique offers a promising alternative strategy to address the ongoing opioid crisis.
Related Concept Videos
Opioid Analgesics: Synthetic and Semisynthetic Opioids
866
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
866
Analgesia and Pain Management
1.4K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.4K
Opioid Analgesics: Morphine and Other Natural Cogeners
792
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
792

