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Related Concept Videos

Cells Coordinate Growth and Proliferation02:36

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Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
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Molecular Factors Affecting Cell Division01:27

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Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
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The Cell Cycle Control System02:11

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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
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Distribution of Cytoplasmic Content02:33

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Cytokinesis segregates a cell’s chromosomes and organelles into its daughter cells. Organelles divide and grow prior to cell division but cannot be synthesized de novo; therefore, cells must receive at least one copy of each organelle to survive. Currently, many of the details of how the organelles are distributed are not yet fully elucidated.
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Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
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Double or Nothing? Cell Division and Cell Size Control.

Angharad R Jones1, Leah R Band2, James A H Murray1

  • 1Cardiff School of Biosciences, Cardiff University, Sir Martin Evans Building, Museum Avenue, Cardiff CF10 3AX, UK.

Trends in Plant Science
|October 22, 2019
PubMed
Summary
This summary is machine-generated.

Cell size regulation is crucial for efficient cellular and tissue function. Advances in live imaging and modeling are revealing dynamic mechanisms controlling cell size in plant meristems.

Keywords:
cell cyclecell sizedevelopmentgrowthmulticellularity

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Area of Science:

  • Plant Biology
  • Cell Biology
  • Developmental Biology

Background:

  • Cell size is a fundamental property critical for organismal efficiency.
  • Dynamic cell size control aids unicellular adaptation and multicellular development.
  • Understanding cell size regulation in plant meristems is an emerging area of research.

Purpose of the Study:

  • To explore the mechanisms of cell size regulation in actively dividing plant meristematic tissues.
  • To highlight the role of live cell imaging and modeling in understanding cell size control.
  • To emphasize the necessity of integrated models for predicting cell size and multicellular growth.

Main Methods:

  • Live cell imaging techniques to observe dynamic cellular processes.
  • Computational modeling to simulate cell growth and division.
  • Integration of imaging and modeling data to analyze cell size control mechanisms.

Main Results:

  • Uncovered dynamic mechanisms for cell size control at the cellular level.
  • Demonstrated the importance of coupled advances in live cell imaging and modeling.
  • Provided insights into how cell size is maintained in actively dividing plant tissues.

Conclusions:

  • Integrated models of cell growth and division are essential for predicting cell size.
  • Understanding cellular size control is key to comprehending multicellular growth and development.
  • Further research integrating live imaging and modeling will advance the field of plant developmental biology.