[Combination of Immunotherapy and Hyperthermia]
Yui Kubota1, Tsutomu Takeda, Takashi Takeda
1Dept. of Molecular Pathology, Division of Health Science, Graduate School of Medicine, Osaka University.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|October 22, 2019
Summary
Hyperthermia boosts cancer immunotherapy effectiveness. This study found that combining hyperthermia with immune checkpoint inhibitor and dendritic cell therapy improved treatment outcomes in cancer patients.
Area of Science:
- Oncology
- Immunotherapy
- Cancer Research
Background:
- Cancer treatment often involves a combination of therapies.
- Immune checkpoint inhibitors and dendritic cell therapy are key immunotherapies.
- Enhancing the efficacy of these treatments is a critical research area.
Purpose of the Study:
- To evaluate the impact of hyperthermia on combined immunotherapy.
- To assess the effectiveness of hyperthermia in conjunction with immune checkpoint inhibitor and dendritic cell therapy.
- To investigate the immunological changes induced by hyperthermia.
Main Methods:
- A cohort of 123 cancer patients received combined immune checkpoint inhibitor and dendritic cell therapy.
- Hyperthermia was administered as an adjunct therapy.
- Immunohistochemical staining was used to analyze tumor microenvironment changes in clinical and animal models.
Main Results:
- The combination therapy achieved an effective rate of 51.5%.
- Hyperthermia was observed to enhance radiotherapy, chemotherapy, and immunotherapy.
- Immunohistochemistry revealed increased PD-L1 expression, MHC class I, and CD8 cell infiltration post-hyperthermia.
Conclusions:
- Hyperthermia significantly enhances the efficacy of combined immunotherapy in cancer patients.
- Hyperthermia modulates the tumor microenvironment, increasing immune cell activity and target expression.
- This suggests hyperthermia is a promising strategy to improve outcomes in advanced cancer treatment.
Related Concept Videos
01:27Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
02:50Combination Therapies and Personalized Medicine
5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
01:25Increased Body Temperature
6.3K
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
6.3K
01:19Homeostatic Imbalances in Body Temperature
3.7K
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
3.7K
01:30Cancer Vaccines
913
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
913
02:49Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K