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Updated: Jan 5, 2026

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
Published on: May 27, 2021
Development of New Synthetic Strategies, Tactics and their Applications
Sambasivarao Kotha1, Milind Meshram1
1Department of Chemistry, Indian Institute of Technology Bombay Powai, Mumbai-, 400 076, India.
Abstract:
This account covers our work related to the development of various synthetic methodologies since 1994. We summarized our strategies and their application to design various functional molecules. In this regard, we also report the utility of our methodologies in others research work. These methods we report here are simple and efficient for the synthesis of a wide variety of intricate molecules such as heterocycles, polycycles, unusual α-amino acids, star-shaped molecules, and modified peptides. For this purpose, we used various transition metal-based reagents and catalysts. Various popular reactions such as metathesis, Suzuki coupling, [2+2+2] cyclotrimerization were used to assemble these targets. Moreover, rongalite has been used to expand the Diels-Alder chemistry.
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