Related Experiment Video
Updated: Jan 5, 2026
Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy
Published on: October 13, 2023
Could grape-based food supplements prevent the development of chronic kidney disease?
Jixiao Zhu1,2, Caigan Du2
1Research Center for Traditional Chinese Medicine Resources and Ethnic Minority Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China.
Abstract:
Chronic kidney disease (CKD) is a global health challenge due to its high prevalence, and it increases the risk of development of end-stage renal disease. Although the pathophysiology of CKD is complicated and has not been fully understood, the elevated oxidative stress is considered to play a central role in the development of this disease, thus it becomes an attractive target for CKD prevention or management. The grape extract is one of the rich sources of antioxidants. Literature demonstrates that the consumption of grape antioxidants has significant benefits to the reduction of oxidative stress in different health conditions. In this article, we reviewed the role of the oxidative stress in CKD pathophysiology, and both the preclinical and clinical findings of anti-oxidative activity of proanthocyanidins in grape extracts (catechin, epicatechin, procyanidin B1 and procyanidin), particularly in subjects with CKD. It has been shown that grape-based antioxidants have beneficial effects on chronic metabolic diseases such as diabetes and hypertension, and may also prevent the development of CKD and cardiovascular disease.
Insights
Grape seed extract, rich in antioxidants, shows promise in combating oxidative stress linked to chronic kidney disease (CKD). Research suggests these compounds may help prevent CKD and related cardiovascular issues.
Area of Science:
- Nephrology
- Nutritional Science
- Biochemistry
Background:
- Chronic kidney disease (CKD) is a significant global health concern with increasing prevalence.
- Oxidative stress is a key factor in CKD development, making it a therapeutic target.
- Grape extracts are rich in antioxidants, known to mitigate oxidative stress.
Purpose of the Study:
- To review the role of oxidative stress in CKD.
- To examine the preclinical and clinical evidence of grape proanthocyanidins' antioxidant activity in CKD.
- To assess the potential of grape antioxidants in managing CKD and associated conditions.
Main Methods:
- Literature review of studies on oxidative stress in CKD.
- Analysis of preclinical and clinical data on grape proanthocyanidins (catechin, epicatechin, procyanidin B1, procyanidin).
- Evaluation of findings related to CKD patients and subjects with metabolic diseases.
Main Results:
- Elevated oxidative stress plays a central role in CKD pathophysiology.
- Grape proanthocyanidins exhibit significant antioxidant activity.
- Grape-based antioxidants have demonstrated benefits in chronic metabolic diseases like diabetes and hypertension.
Conclusions:
- Grape-derived antioxidants, particularly proanthocyanidins, show potential for CKD prevention and management.
- These compounds may help reduce oxidative stress and offer protective effects against CKD and cardiovascular disease.
- Further research into grape antioxidants could lead to novel therapeutic strategies for kidney health.
Related Concept Videos
01:28Chronic Kidney Disease III: Interprofessional Care
01:25Chronic Kidney Disease I: Introduction
01:24Chronic Kidney Disease II: Clinical Manifestations
01:18Chronic Kidney Disease IV: Nursing Management
01:27Urinary Tract Calculi IV: Nutrition Therapy and Prevention
01:28Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration