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Clozapine As Transformative Treatment In Bipolar Patients
Alina Wilkowska1, Wiesław J Cubała1
1Department of Psychiatry, Medical University of Gdańsk, Gdańsk, Poland.
Abstract:
Clozapine is an atypical antipsychotic used in treatment-resistant bipolar disorder. There is evidence for its anti-suicidal, anti-aggressive properties and efficacy in substance use comorbidities. Despite guidelines, the drug is used in 1.5% of bipolar patients only. Considering its effectiveness in treatment-resistant cases as well as its epigenetic effects it may become transformative treatment in bipolar disorder impacting the clinical course and psychosocial burden of the disease.
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