Related Experiment Video

Updated: Jan 5, 2026

Author Spotlight: Advancements in Understanding and Combatting Shigella Infections
04:56

Author Spotlight: Advancements in Understanding and Combatting Shigella Infections

Published on: February 9, 2024

1.4K

Shigella: Antibiotic-Resistance Mechanisms And New Horizons For Treatment

Reza Ranjbar1, Abbas Farahani1

  • 1Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Infection and Drug Resistance
|October 22, 2019
PubMed

Insights

Shigella bacteria cause severe dysentery globally. Rising antibiotic resistance necessitates exploring new treatments and vaccines against Shigella infections.

Area of Science:

  • Microbiology and Infectious Diseases
  • Antimicrobial Resistance
  • Drug Discovery

Background:

  • Shigella spp. are a major cause of global morbidity and mortality due to dysentery.
  • Antibiotic therapy is crucial for managing Shigella infections but is increasingly challenged by widespread antibiotic resistance.
  • Mechanisms of resistance include reduced permeability, active efflux pumps, enzyme activity, and target modification.

Purpose of the Study:

  • To review antibiotic resistance mechanisms in Shigella spp.
  • To emphasize the epidemiology and novel resistance acquisition pathways.
  • To discuss emerging therapeutic strategies and vaccine candidates for Shigella infections.

Main Methods:

  • Literature review of antibiotic resistance mechanisms in Shigella.
  • Analysis of epidemiological data on Shigella infections and resistance.
  • Evaluation of current preclinical and clinical research on novel treatments and vaccines.

Main Results:

  • Detailed overview of diverse antibiotic resistance mechanisms in Shigella.
  • Highlighting the increasing prevalence and spread of drug-resistant strains.
  • Identification of promising novel therapeutic approaches and vaccine candidates.

Conclusions:

  • Urgent need for alternative strategies to combat multidrug-resistant Shigella.
  • Continued research into resistance mechanisms and novel interventions is critical.
  • Development of effective vaccines and treatments is essential for controlling Shigella infections.
Keywords:
Shigellaantibioticsbiofilmdrug resistanceefflux pumpsmechanismpreventionresistancetreatmentvaccine

More Related Videos

A High-throughput Shigella-specific Bactericidal Assay06:11

A High-throughput Shigella-specific Bactericidal Assay

Published on: February 27, 2019

12.3K
Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions12:52

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions

Published on: September 9, 2014

16.3K

Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.1K
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
393
Antibiotic Selection00:57

Antibiotic Selection

Overview
59.3K
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
449
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
1.0K
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
6.7K