Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autophagy01:27

Autophagy

5.6K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
5.6K
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

8.7K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
8.7K
Autophagic Cell Death01:18

Autophagic Cell Death

4.3K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.3K
Biosynthesis in Bacteria01:24

Biosynthesis in Bacteria

511
Biosynthesis in bacteria is a fundamental anabolic process that generates essential macromolecules, including proteins, nucleic acids, lipids, and polysaccharides. These macromolecules are critical for cellular growth, replication, and function. The process is tightly regulated and energetically linked to catabolic pathways to ensure optimal resource utilization.Biosynthetic pathways begin with precursor metabolites such as pyruvate, acetyl-CoA, and glucose-6-phosphate derived from glycolysis,...
511
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.5K
Microbial Nutrition01:28

Microbial Nutrition

988
Organisms exhibit remarkable metabolic diversity, categorized based on how they acquire energy and carbon. These strategies enable survival in various ecological niches and are essential for maintaining energy flow and nutrient cycling within ecosystems.Energy and Carbon SourcesOrganisms are classified as phototrophs or chemotrophs based on energy acquisition. Phototrophs use light as their energy source, while chemotrophs rely on oxidizing chemical compounds. Further differentiation arises...
988

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isolation and characterization of phage vB_KpnS_SXK7 against multidrug-resistant Klebsiella pneumoniae and the mechanism of O-antigen-associated phage resistance.

BMC microbiology·2026
Same author

BTNL2 Inhibits Pyroptosis in H37Ra-Infected Macrophages by Maintaining Mitochondrial Homeostasis.

Microorganisms·2026
Same author

A GMP-compliant formulation of regeneratively active polyphosphate for wound healing and skin regeneration.

Biomaterials science·2026
Same author

Structural mechanism of 3'3'-cGAMP-induced filamentation and phospholipid hydrolysis by CapV in bacterial antiphage defense.

Cell reports·2026
Same author

GSK-J4 Suppresses Tumorigenesis by Targeting the PERK-c-Myc Pathway Through Endoplasmic Reticulum Stress Activation in Tuberous Sclerosis Complex.

International journal of molecular sciences·2026
Same author

Hedgehog pathway activity downstream of Smoothened is regulated specifically by basal ciliary PKA.

Cellular & molecular biology letters·2026

Related Experiment Video

Updated: Jan 5, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
07:20

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

1.1K

Bacteria Exploit Autophagy For Their Own Benefit.

Qiuhong Xiong1, Min Yang1, Ping Li1

  • 1Institutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, People's Republic of China.

Infection and Drug Resistance
|October 22, 2019
PubMed
Summary

Many pathogens evade cellular defenses by exploiting autophagy, a cellular recycling process. Bacteria manipulate autophagy to survive and replicate within host cells, evading degradation pathways.

Keywords:
autophagybacteriabenefitexploit

More Related Videos

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions
12:52

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions

Published on: September 9, 2014

16.3K
Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body
06:02

Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body

Published on: August 4, 2022

2.9K

Related Experiment Videos

Last Updated: Jan 5, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
07:20

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

1.1K
Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions
12:52

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions

Published on: September 9, 2014

16.3K
Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body
06:02

Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body

Published on: August 4, 2022

2.9K

Area of Science:

  • Cell Biology
  • Microbiology
  • Immunology

Background:

  • Autophagy is a crucial cellular process for degrading damaged components and pathogens.
  • Xenophagy, a form of autophagy, targets microorganisms for destruction.
  • Pathogens have evolved sophisticated mechanisms to evade or exploit autophagy.

Purpose of the Study:

  • To review bacterial strategies for exploiting the host's autophagy pathway.
  • To understand how bacteria survive and replicate within autophagosomes.

Main Methods:

  • Literature review of current scientific research on autophagy and bacterial pathogenesis.
  • Analysis of documented bacterial effector proteins and host component utilization.

Main Results:

  • Pathogens actively evade autophagic degradation.
  • Bacteria have developed diverse strategies to hijack autophagy for their survival.
  • Mechanisms include inducing autophagy and preventing lysosome fusion.

Conclusions:

  • Bacterial exploitation of autophagy is a significant survival strategy.
  • Understanding these mechanisms is key to developing new therapeutic interventions.
  • Further research is needed to fully elucidate pathogen-autophagy interactions.