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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

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Current Insights Into The Management Of Discoid Lupus Erythematosus

Jaime Company-Quiroga1, Sergio Alique-García1, Alberto Romero-Maté1

  • 1Dermatology Department, Fuenlabrada Univesity Hospital, Madrid, Spain.

Clinical, Cosmetic and Investigational Dermatology
|October 22, 2019
PubMed

Insights

Discoid lupus erythematosus (DLE) treatment focuses on lifestyle and topical therapies. For refractory cases, antimalarial drugs are first-line systemic options, guiding a proposed treatment algorithm.

Area of Science:

  • Dermatology
  • Immunology
  • Rheumatology

Background:

  • Discoid lupus erythematosus (DLE) is a common and disfiguring manifestation of chronic cutaneous lupus erythematosus.
  • While many patients respond to conservative measures, a significant portion requires advanced therapies.

Purpose of the Study:

  • To review evidence-based treatment options for discoid lupus erythematosus.
  • To propose a therapeutic algorithm for managing refractory DLE.

Main Methods:

  • Systematic review of available evidence on DLE treatments.
  • Analysis of treatment modalities based on evidence strength.

Main Results:

  • Lifestyle modifications and topical treatments (corticosteroids, calcineurin inhibitors) have the highest evidence levels.
  • Antimalarial drugs are the primary first-line systemic therapy for DLE.
  • Evidence for other systemic and physical therapies is highly variable.

Conclusions:

  • Topical and lifestyle measures are foundational for DLE management.
  • A structured approach, prioritizing antimalarials, is crucial for refractory DLE.
  • The proposed algorithm aids clinicians in selecting appropriate treatments for persistent DLE.

Keywords:
cutaneous lupus erythematosusdiscoid lupus erythematosusdisease management

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