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Vitamin D Receptor Gene Polymorphism In Chronic Telogen Effluvium; A Case-Control Study.

Iman Seleit1, Ola A Bakry1, Eman Badr2

  • 1Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University, Menoufiya Governorate, Egypt.

Clinical, Cosmetic and Investigational Dermatology
|October 22, 2019
PubMed
Summary
This summary is machine-generated.

Vitamin D receptor (VDR) gene polymorphisms, specifically Taq1 and Cdx1, are linked to chronic telogen effluvium (TE). These genetic variations increase the risk and persistence of hair shedding in affected individuals.

Keywords:
VDRgenepolymorphismtelogen effluvium

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Area of Science:

  • Genetics
  • Dermatology
  • Molecular Biology

Background:

  • Telogen effluvium (TE) is a common cause of diffuse hair shedding.
  • The Vitamin D receptor (VDR) is crucial for hair cycle regulation, with expression in key follicular cells.

Purpose of the Study:

  • To examine the association between VDR gene polymorphisms (Cdx1 and Taq1) and the development of chronic TE.
  • To determine if specific VDR genotypes or alleles correlate with an increased risk of chronic TE.

Main Methods:

  • A case-control study involving 30 female patients with chronic TE and 30 healthy controls.
  • Real-time polymerase chain reaction (PCR) was used to detect Taq1 and Cdx1 VDR gene polymorphisms.

Main Results:

  • The Taq1 CC genotype and C allele were significantly associated with chronic TE, increasing risk by 14.7-fold and 3.1-fold, respectively.
  • The Cdx1 GA genotype and A allele were also significantly linked to chronic TE, elevating risk by 6.3-fold and 3.8-fold, respectively.
  • These findings indicate a strong genetic predisposition to chronic TE associated with specific VDR polymorphisms.

Conclusions:

  • Specific Taq1 and Cdx1 VDR gene polymorphisms are significantly associated with an increased risk of chronic telogen effluvium.
  • These polymorphisms may contribute to the persistence of TE by hindering hair follicle regeneration and stem cell proliferation.
  • Further research is recommended to investigate other types of TE and larger patient cohorts.