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Irinotecan-Induced Skin Dryness Is Ameliorated By Orally Administered High-Dose Vitamin C In Mice
Kentaro Nakanishi1, Kenji Goto1, Kanako Kondo1,2
1Department of Pharmaceutical Science, Suzuka University of Medical Science, Suzuka, Mie 513-8670, Japan.
Background:
Vitamin C plays a part in various roles in the human body. In this study, we examined the effect of oral administration of high-dose vitamin C on the skin dryness induced by irinotecan.
Methods:
To establish the experimental model of irinotecan-induced skin dryness, the drug was intraperitoneally administered for four consecutive days. Simultaneously, oral administration of high-dose vitamin C (4 g/kg) was continued for 4 days.
Results:
High-dose vitamin C administration ameliorated the skin dryness induced by irinotecan. The expression of caspase-3 and caspase-9, reactive oxygen species, and the number of TUNEL-positive cells increased in the skin of irinotecan-treated mice but were lowered by high-dose vitamin C administration. In contrast, fibroblasts and collagen type I decreased in the skin of the irinotecan-treated mice but was increased by high-dose vitamin C administration.
Conclusion:
These results suggested that high-dose vitamin C administration can improve the skin dryness induced by irinotecan.
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