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μECoG Recordings Through a Thinned Skull.

Sarah K Brodnick1, Jared P Ness1, Thomas J Richner1

  • 1Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States.

Frontiers in Neuroscience
|October 22, 2019
PubMed
Summary
This summary is machine-generated.

Researchers developed optically transparent micro-electrocorticography (μECoG) grids for thinned skull preparations. These grids offer stable, long-term electrophysiological recordings and enable optogenetics in mice and rats.

Keywords:
local field potenitalsoptogeneticssomatosensory evoked potentialsthinned skullμECoG

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Electrophysiology

Background:

  • Thinned skull preparations are valuable for optical neuroscience but lack integrated electrophysiology.
  • Existing micro-ECoG arrays require invasive implantation (epidural or subdural).
  • A less invasive method for combined optical and electrical recording is needed.

Purpose of the Study:

  • To characterize the acute and chronic performance of optically transparent thin-film micro-ECoG grids on thinned skulls.
  • To evaluate these grids as an electrophysiological complement to optical methods.
  • To assess their potential as a less invasive alternative to traditional μECoG arrays.

Main Methods:

  • Implantation of optically transparent thin-film μECoG grids on thinned skulls in mice and rats.
  • Longitudinal chronic studies to assess impedance stability over at least 1 month.
  • Acute and chronic electrophysiological recordings using optogenetic and nerve stimulation.
  • Spatial resolution assessment of μECoG electrodes.

Main Results:

  • μECoG grids on thinned skulls demonstrated stable impedances comparable to epidural arrays for over 1 month.
  • Optogenetic cortical activation was reliably demonstrated through the transparent μECoG grids.
  • Spatially distinct electrophysiological recordings were achieved with electrode separations of 500-750 μm.
  • Successful neural signal collection in mice and rats via thinned skull.

Conclusions:

  • Optically transparent μECoG grids on thinned skulls provide a viable, less invasive method for combined electrophysiology and optical techniques.
  • This approach enhances neuroscience research, particularly for in vivo imaging and optogenetics.
  • The technology offers stable chronic performance and good spatial resolution for neural signal detection.