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Updated: Jan 5, 2026
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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Are Migraine With and Without Aura Really Different Entities?
Zsigmond Tamás Kincses1,2, Dániel Veréb1, Péter Faragó1
1Department of Neurology, Faculty of Medicine, Interdisciplinary Excellent Centre, University of Szeged, Szeged, Hungary.
Frontiers in Neurology
|October 22, 2019
Summary
Migraine with aura shows higher brain activity than migraine without aura, suggesting cortical hyperexcitability. Structural MRI results are inconsistent, possibly due to competing plasticity and neurodegeneration mechanisms.
Area of Science:
- Neurology
- Neuroimaging
- Medical Research
Background:
- Migraine research utilizes advanced neuroimaging, particularly MRI, to detect brain alterations.
- Most studies group migraine with aura and migraine without aura, despite evidence of subtype differences.
Purpose of the Study:
- To investigate the differences between migraine with aura and migraine without aura using neuroimaging.
- To clarify the role of structural and functional brain changes in migraine subtypes.
Main Methods:
- Systematic literature search of PubMed using keywords related to migraine subtypes and MRI techniques.
- Analysis of studies comparing "migraine with aura" and "migraine without aura" using functional MRI and diffusion-weighted MRI.
Main Results:
- Few studies directly compare migraine with aura and migraine without aura.
- Functional MRI studies indicate increased brain activity in migraine with aura compared to migraine without aura.
Conclusions:
- Increased brain activity in migraine with aura may signify cortical hyperexcitability.
- Inconsistent structural MRI findings suggest complex underlying mechanisms like maladaptive plasticity and neurodegeneration.
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